LSM2104 Group Project

Weiwei’s Page (U052166X)

Acinetobacter spp. Genome Analysis on Drug Resistance Property

The Acinetobacter calcoaceticus–Acinetobacter baumannii complex comprises 4 closely-related species: A. calcoaceticus, usually found only in the environment; A. baumannii, A. genomospecies 3, and A. genomospecies 13TU, known to be human pathogens. These Gram-negative cocco-bacilli are of relatively low pathogenicity, but are responsible for a significant proportion of nosocomial (hospital-acquired) infections especially in patients with burns or requiring intensive care.

 

A characteristic of these bacteria is their ability to rapidly develop resistance to multiple antibiotics. It is possible for a strain to become effectively pan-antibiotic-resistant and therefore untreatable. Infections with multi-drug resistant Acinetobacter spp. result in longer hospital stay and require treatment with more expensive antimicrobials, contributing to increased morbidity, mortality and health care costs.

 

…Bla bla bla… [Reference: AY0708Sem1_MiniprojectGuidelines]

 

                 My job: take one of the six database, Efflux Pump,

                 First, what is Efflux Pump? Information from other species. [aquamarine in the map]

             Second, where are the regions? Get  the approximate idea.

                 Thrid, dig out the open reading frame in these regions.

                 Fourth, find the functional sites on these ORF.

 

                 That is what I did so far, for CP000522.

 

                                                                    Last update: 20 Sep 2007, Weiwei.